A Coarse-Grained Model for Force-Induced Protein Deformation and Kinetics
نویسندگان
چکیده
منابع مشابه
A coarse-grained model for force-induced protein deformation and kinetics.
Force-induced changes in protein conformation are thought to be responsible for certain cellular responses to mechanical force. Changes in conformation subsequently initiate a biochemical response by alterations in, for example, binding affinity to another protein or enzymatic activity. Here, a model of protein extension under external forcing is created inspired by Kramers' theory for reaction...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2006
ISSN: 0006-3495
DOI: 10.1529/biophysj.104.054841